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Neumora’s KOSTAL-1 Study of Navacaprant Yields Disappointing Results

The study failed to demonstrate a statistically significant improvement in depression symptoms compared to placebo.

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By: Charlie Sternberg

Associate Editor

Neumora Therapeutics Inc. a clinical-stage biopharmaceutical company, has announced results from the Phase 3 KOASTAL-1 Study of navacaprant for the treatment of major depressive disorder (MDD). The study did not demonstrate a statistically significant improvement on the primary endpoint of change from baseline in the Montgomery-Åsberg Depression Rating Scale (MADRS) total score at Week 6 or the key secondary endpoint of a change from baseline in the Snaith-Hamilton Pleasure Scale (SHAPS) scal...

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